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Target and temporal pattern selection at neocortical synapses.

机译:新皮层突触的目标和时间模式选择。

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摘要

We attempt to summarize the properties of cortical synaptic connections and the precision with which they select their targets in the context of information processing in cortical circuits. High-frequency presynaptic bursts result in rapidly depressing responses at most inputs onto spiny cells and onto some interneurons. These 'phasic' connections detect novelty and changes in the firing rate, but report frequency of maintained activity poorly. By contrast, facilitating inputs to interneurons that target dendrites produce little or no response at low frequencies, but a facilitating-augmenting response to maintained firing. The neurons activated, the cells they in turn target and the properties of those synapses determine which parts of the circuit are recruited and in what temporal pattern. Inhibitory interneurons provide both temporal and spatial tuning. The 'forward' flow from layer-4 excitatory neurons to layer 3 and from 3 to 5 activates predominantly pyramids. 'Back' projections, from 3 to 4 and 5 to 3, do not activate excitatory cells, but target interneurons. Despite, therefore, an increasing complexity in the information integrated as it is processed through these layers, there is little 'contamination' by 'back' projections. That layer 6 acts both as a primary input layer feeding excitation 'forward' to excitatory cells in other layers and as a higher-order layer with more integrated response properties feeding inhibition to layer 4 is discussed.
机译:我们试图总结皮层突触连接的属性以及在皮层回路信息处理中它们选择目标的精度。高频突触前突触导致棘突细胞和某些中间神经元的大多数输入信号快速抑制。这些“阶段性”联系发现了新颖性和射击频率的变化,但报告维持活动的频率很差。相比之下,促进针对树突的中间神经元的输入在低频下几乎不产生响应,或者不产生响应,但是对持续激发产生增强响应。神经元被激活,它们依次靶向的细胞以及那些突触的特性决定了电路的哪些部分被募集以及以何种时间模式被募集。抑制性中间神经元提供时间和空间调节。从第4层兴奋性神经元到第3层以及从3到5的“向前”流动主要激活金字塔。从3到4和5到3的“后向”投影不会激活兴奋性细胞,但会靶向中间神经元。因此,尽管在通过这些层进行处理时集成的信息的复杂性不断增加,但是“反向”预测几乎没有“污染”。讨论了该层6既充当主要输入层,向其他层中的兴奋性细胞馈送激发“正向”,又充当具有更高综合响应特性的较高阶层,向层4馈入抑制。

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